Desperation for a cure drives Caleb into unethical territory as his experiments on both the Hounds and himself deepen.
He explores fusing bio-chemical augments, mechanised implants, the arcane and the darker compounds of Serum. Mutating beyond recognition, he is rejected by his wife who recoils in the horror of what he has become.
Upon discovering Caleb's distortion, Blaksoot immediately decommissions Project Serum. Consumed by his experiments, Caleb is exiled and seeks the secrecy of the pits below Serum City where he continues to experiment on fusing the Hounds for a cure.
An olive branch by a close confidant of Blaksoot’s inner circle is later offered. Redemption to cure himself and his wife and a bridge back to all that he’s lost.
He provides Caleb with the funds and resources to intensify his experiments on the DNA of Mutant Hounds and that dark serum will unlock the cure.
Caleb religiously journals his experiments and his own Mutation as what's left of his Apemanity slips away.

This libertine was born on the side of the coin that royalty had its back to, known to frequent the many watering holes of Serum City and share the stalls with its bruisers and barflies. His roots are anything but royal, armed with an extensive armoury of language and overly flamboyant clothing, he has crafted a convincing veneer of regality that grants him an audience in every room, although he tends to prefer those with a fully stocked bar. Whether it’s permanent inebriation or his poetic leanings, everything he delivers is wrapped in allegory and conceits that require footnotes to fully grasp.
Information flows freely in the drinking dens he frequents, and that's the currency he uses to manipulate the Cartel's operations, carving out a kingdom in the gutter. He knows its alleyways better than the rats themselves, and very little moves in this place without The Duke pulling a string, lighting a fire, or whispering in an ear. Though he may be the loudest peacock on the cobbles, the moves he makes to sow others fates are never seen.
